The Holiday Special begins two weeks before Christmas with Apollo 8 poised to circle the moon. Sister Monica Joan (Judy Parfitt) is convinced this could be her last Yuletide and decides she’ll not live to see man walk on the moon. The Nonnatus Family, including Trixie’s (Helen George) brother Geoffrey (Christopher Harper), decide something must be done to try and lighten her state of mind. Nancy (Megan Cusack) has recommitted to staying at Nonnatus House and Sister Julienne (Jenny Agutter) has offered her and Colette (Francesca Fullilove) a room for the foreseeable future.
Trixie and Matthew (Olly Rix), fresh from their honeymoon, are preparing their first Christmas together as husband and wife when Geoffrey pays them an unexpected visit days before Christmas. Cyril (Zephryn Taitte) gently intervenes when he discovers a lost soul living alone in a dilapidated basement flat. For this man, Christmas is a reminder of all he’s lost and all he’s never had. Nurse Crane (Linda Bassett), away on her refresher course, makes it home in time for Christmas festivities despite a treacherously heavy snowfall.